Carfilzomib (Kyprolis)

How does this medicine work?
Carfilzomib (kar-filz-oh-mib) is a biological cancer medicine known as a proteasome inhibitor. It works to destroy cancer cells by causing the buildup of certain proteins that cause the cell to die.  

How is the medicine given?
Carfilzomib is given into a vein (IV) by an infusion in the hospital. Prior to the infusion, adequate hydration is required; your oncologist will order IV fluids. To prevent or lessen infusion reactions, you will be pre-medicated with dexamethasone 30 minutes prior to the Carfilzomib infusion.

What are the side effects?

Common:

• Low blood cell counts        
• Diarrhea
• Fatigue
• Cough
• Fever
• Upper respiratory infection
• Decreased potassium levels
• Headaches
• Shortness of breath
• Swelling of feet and legs

Occasional:

• Pain, burning, numbness, or tingling of the hands or feet (peripheral neuropathy)
• Muscle spasms
• High blood pressure

Rare:

• Acute kidney failure
• Pulmonary embolism
• Heart failure
• Deep vein thrombosis
• Liver failure

When should I call the clinic?

Call the clinic if:

• Fever, bleeding, unusual bruising
• Swelling of feet or legs
• Cough, shortness of breath
• Pain, burning, numbness, tingling
• Seizure, loss of consciousness
• Confusion, hallucinations, memory loss
• Decreased urination
• Signs of an allergic reaction:
  
  • rash or hives
  • wheezing
  • trouble breathing - call 911

What else do I need to know?

• If you are sexually active it is very important to use 2 methods of birth control throughout this treatment and for at least 30 days after completion of Carfilzomib.
• All caregivers should wear gloves when handling urine, stool, and vomit while your child is receiving chemotherapy and for 48 hours afterward. Urine, stool, and vomit can be safely disposed of in septic tanks and the sewer system.
• Any clothes or bed linens that are contaminated with urine, stool, or vomit should be washed separately from other laundry in hot water and detergent. Anyone handling the contaminated laundry should wear gloves.
• You will have regular blood tests while receiving this medication. This is to make sure your all your heart, lungs, and kidneys are working properly.

Questions?

If you have any questions, please call the oncology clinic or pharmacy.

Last reviewed Hem/Onc 6/2015.

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